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KMID : 0616120120430020163
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 2 p.163 ~ p.166
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Antiallergic and Anti-inflammatory Effects of Perilla frutescens var. acuta
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You Jin-Su
Kim Sang-Yong
Kim Sang-Hyun
Shin Tae-Yong
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Abstract
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In the present study, we investigated the effect of the water extract of Perilla frutescens var. acuta (Labiatae; WEPF) on the mast cell-mediated allergic reactions. WEPF was anally administered to mice for high and fast absorption. WEPF inhibited compound 48/80-induced systemic allergic reaction. WEPF attenuated immunoglobulin E (IgE)-mediated local allergic reaction. In addition, WEPF decreased the gene expression of pro-inflammatory cytokines in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated HMC-1 cells. These results indicate that WEPF inhibits mast cell-mediated allergic reactions in vivo and in vitro.
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KEYWORD
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Perilla frutescens var. acuta, Allergic inflammation, Mast cell, Tumor necrosis factor-, Interleukin-6
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